Newswise — This article discusses the interplay between colorectal cancer (CRC) stem cells, tumor microenvironment (TME), and gut microbiota, emphasizing their dynamic roles in cancer progression and treatment resistance. It highlights the adaptability of CRC stem cells, the bidirectional influence of TME, and the multifaceted impact of gut microbiota on CRC. The manuscript proposes innovative therapeutic strategies focusing on these interactions, advocating for a shift towards personalized and ecosystem-targeted treatments in CRC. The conclusion underscores the importance of continued research in these areas for developing effective, personalized therapies.
Key Words: Colorectal cancer; Stem cells; Tumor microenvironment; Gut microbiota; Treatment resistance; Therapeutic strategies; Personalized medicine; Cancer ecosystem; Research advancements
Core Tip: The core objective of this article is to build upon the compelling arguments presented in the review, highlighting emerging trends, and introducing fresh perspectives to delve deeper into the intricacies of the interplay among these factors. A profound understanding of this interactive relationship is of paramount importance, as it holds the key to unlocking entirely new colorectal cancer treatment strategies and significantly improving patient prognosis.
