April 24, 2025

Stem Cells

MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model | Newswise

MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model | Newswise

David Bale03 mins

BACKGROUND Newswise — Heart disease remains a leading cause of mortality worldwide, with existing treatments often failing to effectively restore damaged myocardium. Human-induced pluripotent stem cells (hiPSCs) and their derivatives offer promising therapeutic options; however, challenges such as low retention, engraftment issues, and tumorigenic risks hinder their clinical utility. Recent focus has shifted to exosomes…

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MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model | Newswise

Cyclodextrin Host-Guest Complex to Facilitate Sinomenine-Based Osteoporosis Therapy | Newswise

David Bale03 mins

Newswise — Xiao et al reported on the natural product sinomenine (SIN), which is a traditional Chinese medicine for treating osteoporosis via its modulation of autophagy; however, SIN was dissolved in dimethyl sulfoxide prior to administration, which is not conducive to the development of clinical injectables. By comparing solubilization techniques, including amorphisation, emulsification, micellisation, nano-crystallisation…

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MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model | Newswise

Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia | Newswise

David Bale03 mins

BACKGROUND Newswise — Mesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics. Different sources of MSCs or culture systems may cause heterogeneity of exosomes. AIM To define the potential of human adipose-derived MSC…

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MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model | Newswise

Emerging Role of Mesenchymal Stem Cell-Derived Exosomes in the Repair of Acute Kidney Injury | Newswise

David Bale02 mins

Newswise — Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid deterioration in kidney function and has a significant impact on patient health and survival. Mesenchymal stem cells (MSCs) have the potential to enhance renal function by suppressing the expression of cell cycle inhibitors and reducing the expression of senescence markers and…

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New Technique Reveals How the Same Mutations Give Rise to Very Different Types of Leukaemia | Newswise

New Technique Reveals How the Same Mutations Give Rise to Very Different Types of Leukaemia | Newswise

David Bale05 mins

Newswise — Barcelona, 25 February 2025 – Myeloid leukaemias are among the most aggressive blood cancers and have low survival rates. Today, leukaemia patients undergo genetic analysis to identify mutations and select the most appropriate treatment. However, even among patients with the same mutation, disease progression and response to therapy can vary significantly. A study…

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Study Sheds Light on Liver Maturation, Specialization | Newswise

Study Sheds Light on Liver Maturation, Specialization | Newswise

David Bale08 mins

BYLINE: Jeni Bushman, School of Molecular & Cellular Biology Newswise — Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes. Their findings, published in Genes and Development, provide insight into hepatocyte specialization that will aid efforts in…

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MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model | Newswise

Microvesicles Derived From Mesenchymal Stem Cells: A Promising Therapeutic Strategy for Acute Respiratory Distress Syndrome-Related Pulmonary Fibrosis? | Newswise

David Bale02 mins

Newswise — Pulmonary fibrosis significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), markedly increasing patient mortality. Despite the established anti-fibrotic effects of mesenchymal stem cells (MSCs), numerous challenges hinder their clinical application. A recent study demonstrated that microvesicles (MVs) from MSCs (MSC-MVs) could attenuate ARDS-related pulmonary fibrosis and enhance lung function via…

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Could Fecal Microbiota Transplantation Help Patients Heal After Stem Cell Transplantation? | Newswise

Could Fecal Microbiota Transplantation Help Patients Heal After Stem Cell Transplantation? | Newswise

David Bale010 mins

Newswise — SEATTLE — Jan. 28, 2025 — A new study shows that oral fecal microbiota transplantation (FMT) is a feasible and safe addition to preventing graft-versus-host disease in patients undergoing stem cell transplantation for blood cancers. The study, published Jan. 25 in Nature Communications, is part of a phase 2 clinical trial led by…

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Deep Imaging Reveals Hidden Secrets of Cells Within the Bone Marrow Niche | Newswise

Deep Imaging Reveals Hidden Secrets of Cells Within the Bone Marrow Niche | Newswise

David Bale07 mins

Newswise — Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to accurately identify rare LepR+ stromal cells. Traditional imaging techniques have struggled to capture these elusive cell populations and the sparse structures of bone marrow….

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