Stem Cells

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Bone Marrow Mesenchymal Stem Cells Promote Uterine Healing by Activating the pi3k/Akt Pathway and Modulating Inflammation in Rat Models | Newswise

David Bale3 months ago04 mins

BACKGROUND Newswise — Uterine injury can cause uterine scarring, leading to a series of complications that threaten women’s health. Uterine healing is a complex process, and there are currently no effective treatments. Although our previous studies have shown that bone marrow mesenchymal stem cells (BMSCs) promote uterine damage repair, the underlying mechanisms remain unclear. However,…

First of Its Kind Gene Therapy Model Offers Hope f | Newswise

David Bale4 months ago07 mins

Newswise — Philadelphia January 2, 2025 Researchers at Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania Perelman School of Medicine pioneered a first of its kind gene therapy model that offers a potential breakthrough in treating X-linked sideroblastic anemia (XLSA), a rare congenital anemia caused by mutations in the ALAS2 gene crucial for…

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Preliminary Evidence of Renal Function Improvement | Newswise

David Bale4 months ago04 mins

BACKGROUND Newswise — To date, no specific treatment has been established to reverse progressive chronic kidney disease (CKD). AIM To evaluate the safety and efficacy of autologous CD34+ cell transplantation in CKD patients who exhibited a progressive decline in renal function. METHODS The estimated glomerular filtration rate (eGFR) at the beginning of the study was…

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Innovative Hydrogel Delivery of Bone Marrow Stroma | Newswise

David Bale4 months ago03 mins

Newswise — Bone regeneration is a multifaceted process involving the well-coordinated interaction of cellular functions such as the regulation of inflammation, the formation of new blood vessels, and the development of bone tissue. Bone regeneration is a multifaceted process involving the well-coordinated interplay of multiple cellular activities, such as inflammation control, blood vessel and bone…

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Exosomes Derived From microRNA-540-3p Overexpressi | Newswise

David Bale4 months ago04 mins

BACKGROUND Newswise — Heart transplantation is a crucial intervention for severe heart failure, yet the challenge of organ rejection is significant. Bone marrow mesenchymal stem cells (BMSCs) and their exosomes have demonstrated potential in modulating T cells, dendtitic cells (DCs), and cytokines to achieve immunomodulatory effects. DCs, as key antigen-presenting cells, play a critical role…

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Interplay and Therapeutic Implications of Colorect | Newswise

David Bale4 months ago02 mins

Newswise — This article discusses the interplay between colorectal cancer (CRC) stem cells, tumor microenvironment (TME), and gut microbiota, emphasizing their dynamic roles in cancer progression and treatment resistance. It highlights the adaptability of CRC stem cells, the bidirectional influence of TME, and the multifaceted impact of gut microbiota on CRC. The manuscript proposes innovative…

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ASH: Triplet combination regimens demonstrate high | Newswise

David Bale5 months ago011 mins

ABSTRACTS: 216, 219, 1011 Newswise — SAN DIEGO ― Three clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated significant positive results from novel triplet therapies in the treatment of relapsed or refractory and newly diagnosed leukemias. The results were presented at the 66th American Society of Hematology (ASH) Annual Meeting…